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Research & Scholarly Activities
Current research foci:
1. Mitochondrial dysfunction and selfish evolutionary dynamics:
- transmission dynamics of deletion-bearing mitchondrial DNA (mtDNA) in C. briggsae
- evolutionary causes and consequences of selfish DNA in C. briggsae
- evolution of mtDNA copy number in C. elegans
- mutational and phenotypic impacts of endogenous oxidative stress in C. elegans mutants with dysfunctional mitochondria
- the role of heteroplasmy in mtDNA evolution
2. Compensatory mutation and the experimental evolution of adaptation:
- genome-wide surveys for compensatory mutation in C. elegans recovery line systems
- experimental evolution of resistance to external sources of oxidative stress in C. elegans
3. Nematode biodiversity and phylogenetics:
- uncovering cryptic genetic diversity in Xiphinema plant-parasitic ("dagger") nematodes
- high-throughput sequencing of complete mitochondrial genomes in Caenorhabditis nematodes
- discovery of new nematode species and strains in unusual environments
4. Evolutionary genetics and genomics in sea anemones:
- investigating accelerated evolutionary rates in selfish genes occupying anemone mitochondrial genomes
- development of Aiptasia as a model anemone system for evolutionary analysis: evolution of natural populations, experimental evolution approaches
5. The intersection of Madhyamaka Buddhism and scientific perspectives.
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